Abstract: To develop antibacterial materials with high antibacterial activity and biocompatibility of high demand for public health and safety, in this work, we have successfully synthesized Pt@ MXene composites (PMCs),which possess excellent oxidase-like activity and show the activity of inhibition of both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli) with high efficiency. The antibacterial mechanism revealed that PMCs had both excellent oxidation enzyme activity with corresponding electron transfer ability and large specific surface area, which led to the effective inhibition of the growth of bacteria. Moreover, the designed system showed excellent wound healing ability in vivo with good biocompatibility. Therefore, this work has not only proposed an effective way in designing and exploring nanozyme-like antibacterial materials, but also demonstrated the promising potential of application of PMCs in disinfection and wound-healing therapy.

Key words: nanozymes, antibacterial, Pt@ MXene, wound healing, electron transfer